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情况简介
院士风采
杰出青年
全所PI名录
 
 
地址:上海市岳阳路320号
邮编:200031
电话:86-21-54920000
传真:86-21-54921011
邮箱:sibcb@sibcb.ac.cn

全所PI名录 >

 
胡苹
研究员
E-mail: hup@@sibcb.ac.cn


个人简介

1998年毕业于北京大学生命科学院,2003年于State University of New York, Stony Brook与Cold Spring Harbor Laboratory合作开办的研究生项目获得博士学位,随后在Cold Spring Harbor Laboratory和University of California, Berkeley从事博士后研究。现任中国科学院上海生物化学和细胞生物学研究所研究员,研究组长。


研究方向

成体干细胞的命运决定


研究工作

        胡苹实验室主要从事骨骼肌再生与衰老的研究,致力于骨骼肌干细胞保持、增殖微环境的研究,阐明骨骼肌干细胞在衰老、多种骨骼肌退行性疾病、肿瘤等生理病理条件下的演变规律,为抗衰老、骨骼肌退行性疾病的细胞和抗体治疗提供提供新策略和新方法。同时对骨骼肌稳态维持和衰老的机理进行研究,探究骨骼肌的代谢与内分泌功能与其再生和衰老的调控关系,揭示骨骼肌与其它器官之间的相互作用,并揭示再生、衰老与器官间相互作用的转录与表观遗传调控机制。在理解体内再生、衰老和疾病发生的机理的基础上,在体外重建健康肌肉组织,在细胞、动物模型中进行衰老和肌肉退行性疾病的治疗方法研究,并进行相关的临床转化研究。


代表性论文

  1. VGLL4 acts from a repressor to an activator in muscle regeneration. Xue Feng, Zuoyun Wang, Fei Wang, Jinjin Xu, Tiantian Lu, Xueyan Ma, Jinhui Li, Lingli He, Wenxiang Zhang, Sheng Li, Wenjun Yang, Lili Han, Shu Zhang, Gaoxiang Ge, Yun Zhao,2, Ping Hu*, and Lei Zhang1,2,* EMBO J. Accepted June 5, 2019.
  2. Skeletal muscle regeneration is modulated by inflammation. Wenjun Yang & Ping Hu*. Journal of Orthopaedic Translation. Accepted on Jan. 6, 2018.
  3. Dkk3 dependent transcriptional regulation controls ageing induced skeletal muscle atrophy. Jie Yin, Lele Yang, Yangli Xie, Yan Liu, Sheng Li, Wenjun Yang, Bo Xu, Hongbin Ji, Kun Wang, Gang Li, Lin Chen & Ping Hu*. Nature Communications. Accepted on Dec. 16, 2017.
  4. Hierarchical signaling transduction of the immune and muscle cell crosstalk in muscle regeneration. Wenjun Yang and Ping Hu*. Cell Immunol. 2017 Aug 24.
  5. MyoD and FoxO3 mediated hotspot interaction orchestrates super-enhancer activity during myogenic differentiation. Yu Zhao, Bo Xu, Hao Sun, Ping Hu, Huangting Wang. Nucleic Acid Research, 45 (15): 8785–8805, 2017..
  6. Characterization and isolation of highly purified porcine satellite cells. Shijie Ding, Fei Wang, Yan Liu, Sheng Li, Guanghong Zhou,* and Ping Hu*. Cell Death Dis. 10(3):17003-17009, 2017.
  7. Characterization of mesoderm lineage. Wenjun Yang and Ping Hu*. Science in China (Series C:Life Sciences) , 08, pp 849-855, 2016.
  8. Hierarchical signaling transduction of the immune and muscle cell crosstalk in muscle regeneration. Wenjun Yang and Ping Hu*. Cell Immunol. 2017 Aug 24.
  9. MyoD- and FoxO3-mediated hotspot interaction orchestrates super-enhancer activity during myogenic differentiation. Xianlu Peng, Karl K So, Liangqiang He, Yu Zhao, Jiajian Zhou, Yuying Li, Mingze Yao, Bo Xu, Suyang Zhang, Hongjie Yao, Ping Hu, Hao Sun and Huating Wang Nucleic Acids Res. 2017 Jun 1.
  10. Characterization and isolation of highly purified porcine satellite cells.Shijie Ding, Fei Wang, Yan Liu, Sheng Li, Guanghong Zhou,* and Ping Hu*. Cell Death Dis. 2017 Apr 10;3:17003.
  11. Characterization of mesoderm lineage. Wenjun Yang and Ping Hu*. Science in China(Series C:Life Sciences) , 08, pp 849-855, 2016.
  12. In vitro Differentiation of ESCs/iPSCs to Myogenic Lineage: Moving towards Cell Therapy.
    Julieta Gasparri and Ping Hu*. Experimental and Molecular Medicine 2016,1(1):9-12.
  13. A muscle secretive protein Msp marks ageing related muscular dystrophy. Jie Yin, Yan Liu, Wenjun Yang and Ping Hu*. Journal of Cachexia Sarcopenia and Muscle. 2015, 6: 409-413.
  14. Combination of inflammation-related cytokines promotes long-term muscle stem cell expansion. Xin Fu, Jun Xiao, Yuning Wei, Sheng Li, Yan Liu, Kun Sun, Hao Sun, Huating Wang, Zongkang Max Zhang, Baoting Zhang, Chun Sheng, Hongyan Wang*, and Ping Hu*. Cell Research. 2015 Jun;25(6):655-73.( cover story with preview)
  15. Stem cell activation in skeletal muscle regeneration. Xin Fu, Huating Wang, and Ping Hu*. Cellular and Molecular Life Sciences. 2015 May;72(9):1663-77. 
  16. Stem Cell and Regenerative Medicine, Chapter 10. Ping Hu. People’s Health Publishing House. 2014. ISBN978—7-117-19242-2/R-19243.
  17. Mll2 controls cardiac lineage differentiation of mouse embryonic stem cells by promoting H3K4me3 deposition at cardiac-specific genes. Xiaoling Wan, Lulu Liu, Peipei Zhou, Zhouzhong Wen, Ping Hu, Bing Zhou and Yan Zhang. Stem Cell Reviews and Reports. 2014 Oct;10(5):643-52.
  18. Stimulation of Somatic Cell Reprogramming by ERas-Akt-FoxO1 Signaling Axis.Yong Yu, Dan liang, Qing Tian, Xiaona Chen, Bo jiang, Bin-kuan Chou, Ping Hu, Linzhao Cheng, Ping Gao, Jinsong Li and Gang Wang. Stem Cells. 2014 Feb;32(2):349-63.
  19. Forkhead transcription factors control stem cell fate determination. Jie Yin, Yuyin Yi, Xin Fu, and Ping Hu*. Chinese Journal of Cell Biology. 2012, 34(12): 1197-1206.
  20. Genome-wide roles of Foxa2 in directing liver specification. Chenhuan Xu, Xiaowen Lv, Zhang Chen, Zhiying He, Guangpeng Li, Yue Ma, Lijian Hui, Bin Xie, Yuan Gao, Xiaoyan Ding, Yiping Hu, Ping Hu *, Jing-Dong J. Han*, and Xin Wang. J Mol Cell Biol. 2012, 4(6), 420-422.
  21. Sub-Nuclear Spatial Segregation of Genes and Core Promoter Selectivity Factors. Jie Yao, Richard D. Fetter, Ping Hu, Eric Betzig and Robert Tjian. Genes and Development. 2011, 25(6):569-80..
  22. Co-dependent Activators Direct Myoblast Specific MyoD Transcription. Ping Hu, Kenneth G. Geles, Ji-Hye Paik, Ronald A. DePinho, and Robert Tjian. Developmental Cell. 2008, Oct; 15(4): 534-546.
  23. MyoD targets TAF3/TRF3 to activate myogenin transcription. Maria DE. Deato, Michael T. Marr, Theo Sottero, Carla Inouye, Ping Hu and Robert Tjian. Molecular cell. 2008, Oct 10; 32(1):96-105.

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